The NSABP Foundation is a not-for-profit academic research organization with over a 60-year history of conducting ground-breaking research studies in breast and colorectal cancer. The NSABP Foundation is an outgrowth of the National Surgical Adjuvant Breast and Bowel Project, instituted in 1958 as part of the National Cancer Institute's clinical trials program. In its history the NSABP has enrolled more than 110,000 women and men in clinical trials in breast and colorectal cancer. We have research sites at nearly 700 major medical centers, university hospitals, large oncology practice groups, and health maintenance organizations in the United States, Canada, and Ireland. At those sites and their satellites, about 5000 physicians, nurses, and other medical professionals conduct NSABP treatment and prevention trials.